CALL FOR PAPERS Endocrine and Metabolic Dysfunction During Aging and Senescence Intake of low-dose leucine-rich essential amino acids stimulates muscle anabolism equivalently to bolus whey protein in older women at rest and after exercise
نویسندگان
چکیده
Syed S. I. Bukhari,* Bethan E. Phillips,* Daniel J. Wilkinson, Marie C. Limb, Debbie Rankin, William K. Mitchell, Hisamine Kobayashi, Paul L. Greenhaff, Kenneth Smith, and Philip J. Atherton Medical Research Council/Arthritis Research United Kingdom Centre of Excellence for Musculoskeletal Ageing Research, University of Nottingham, Derby, United Kingdom; and Ajinomoto Company Incorporated, Tokyo, Japan
منابع مشابه
Intake of low-dose leucine-rich essential amino acids stimulates muscle anabolism equivalently to bolus whey protein in older women at rest and after exercise.
Dysregulated anabolic responses to nutrition/exercise may contribute to sarcopenia; however, these characteristics are poorly defined in female populations. We determined the effects of two feeding regimes in older women (66 ± 2.5 yr; n = 8/group): bolus whey protein (WP-20 g) or novel low-dose leucine-enriched essential amino acids (EAA) [LEAA; 3 g (40% leucine)]. Using [(13)C6]phenylalanine i...
متن کاملCALL FOR PAPERS Endocrine and Metabolic Dysfunction during Aging and Senescence The impact of delivery profile of essential amino acids upon skeletal muscle protein synthesis in older men: clinical efficacy of pulse vs. bolus supply
Mitchell WK, Phillips BE, Williams JP, Rankin D, Lund JN, Wilkinson DJ, Smith K, Atherton PJ. The impact of delivery profile of essential amino acids upon skeletal muscle protein synthesis in older men: clinical efficacy of pulse vs. bolus supply. Am J Physiol Endocrinol Metab 309: E450–E457, 2015. First published July 7, 2015; doi:10.1152/ajpendo.00112.2015.—Essential amino acids (EAA) are res...
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BACKGROUND Decreased ability of muscles to respond to anabolic stimuli is part of the underlying mechanism for muscle loss with aging. Previous studies suggest that substantial amounts of essential amino acids (EAA), whey protein and leucine are beneficial for stimulation of acute muscle protein synthesis in older adults. However, these studies supplied only proteins, and no bolus studies have ...
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BACKGROUND Leucine is a key amino acid involved in the regulation of skeletal muscle protein synthesis. OBJECTIVE We assessed the effect of the supplementation of a lower-protein mixed macronutrient beverage with varying doses of leucine or a mixture of branched chain amino acids (BCAAs) on myofibrillar protein synthesis (MPS) at rest and after exercise. DESIGN In a parallel group design, 4...
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PURPOSE OF REVIEW Sarcopenia (skeletal muscle wasting with aging) is thought to underlie a number of serious age-related health issues. While it may be seen as inevitable, decreasing this gradual loss of muscle is vital for healthy aging. Thus, it is imperative to investigate exercise and nutrition-based strategies designed to build a reservoir of muscle mass as early as possible. RECENT FIND...
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